The Kids of Kayele is an online game that uses video, photos, trivia and interactive game play, to teach students about global water and sanitation issues. Players assume the role of exchange students that must maintain the health of their friends, while visiting Zambia. Through the game students learn about human impact on water quality, microbiological contamination, current practices and technologies that affect water quality and problems that require both technological and social solutions. The clues to stay healthy during the game are provided by the Kids of Kayele, a group of youth from a hygiene club in Zambia. This resource includes a lesson plan explaining how to play the video game, as well as a lesson to debrief learning.